ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Diabetes Care. 2019;42:1297–1304In normal populations, high BMI is associated with higher mortality and morbidity, in particular from cardiovascular disease (CVD). In contrast, in type 1 diabetes (T1D), low body weight has been associated with increased mortality risks. This study investigated the importance of weight and weight gain/loss in patients with ...

To read the full abstract: BMJ 2018;360:k452The role of thyroid hormones during early gestation is well established by animal studies. In humans, previous studies have shown that maternal hypothyroxinemia was associated with either an early reduction in psychomotor scales (e.g. Bayley scale of infant development) or later in late infancy or adolescence. However, randomized controlled trials on...

To read the full abstract: Circulation. 2019;139:1900–1912Numerous publications have reported that higher HbA1c levels relate to higher cardiovascular disease (CVD) risk in people with type 1 diabetes (T1D). However, the strength of association and optimal HbA1c levels are not established.This analysis of T1D patients recorded in the Swedish National Diabetes ...

Brief summary: Over the last decades changing incidences for autoimmune diseases have been observed. However, no data are available so far on long-term trends, incidence over the whole age spectrum (child, adults, geriatric patients), and incidence of co-occurrence of the different autoimmune diseases. The presented study provides an extensive population-based cohort study performed in the UK.The authors used electronic health care records of 22 million ...

Brief Summary: This double-blind, placebo-controlled international trial, randomized overweight and obese adults with T2D to either once-weekly subcutaneous Tirzepatide (10 mg or 15 mg) or placebo for 72 weeks. Tirzepatide led to weight reductions of -9.6% with the 10 mg dose and -11.6% with the 15 mg dose, compared to placebo. From a mean baseline 8.0%, HbA1c reduced by –2·1% with both the 10 mg, and 15 mg dose of triszepatied compared to 0·5% reduction on plac...

Sci Transl Med. 2022 Apr 6;14(639):eabj9625; PMID 35385337 doi: 10.1126/scitranslmed.abj9625https://www.science.org/doi/10.1126/scitranslmed.abj9625Brief Summary: This international study, led by Dr. Stephens Williams from Boulder, Colorado, USA, developed a surrogate biomarker from 27 circulating proteins to predict ...