ESPE Yearbook of Paediatric Endocrinology

Brief Summary:This basic science study, using mice, cell models, and organoids, shows that the cAMP-binding protein EPAC1 is a central regulator of adaptive brown adipose tissue (BAT). EPAC1 specifically increases the number of thermogenic fat cells (brown and beige adipocytes), by promoting the differentiation and growth of brown adipocytes and the development of beige adipocytes through signaling pathways that enhance lipid metabolism and thermogenesis.<p class="abstext"...