ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0019.1-4 | Basic Science and Stem Cells | ESPEYB19

1.4. Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

P Russell John , Lim Xinhong , Santambrogio Alice , Yianni Val , Kemkem Yasmine , Wang Bruce , Fish Matthew , Haston Scott , Grabek Anae¨lle , Hallang Shirleen , J Lodge Emily , L Patist Amanda , Schedl Andreas , Mollard Patrice , Nusse Roel , Andoniadou Cynthia L

Elife. 2021 Jan. 10:e59142. doi: https://doi.org/10.7554/eLife.59142.Brief Summary: The authors studied genetic mice models to show that pituitary stem cells can secrete WNT ligands to their committed progeny and promote their expansion.The anterior pituitary contains a population of Sox2 expressing stem cells (Sox2+ PSCs), which self-renew and give rise to lineage...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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