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8.3 Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man

K Kalafatakis , GM Russell , CJ Harmer , MR Munafo , N Marchant , A Wilson , JC Brooks , C Durant , J Thakrar , P Murphy , NJ Thai , SL Lightman

To read the full abstract: Proc Natl Acad Sci U S A. 2018; 115(17): E4091-E4100The hypothalamic-pituitary-adrenal axis is a critical neurohormonal network that regulates homeostasis and coordinates the stress response. Glucocorticoids (GCs) are critical for life and are key regulators of cognitive, metabolic and immunologic homeostasis (4). Clinical studies in healthy human subjects, usi...

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ey0021.4-13 | New Perspectives | ESPEYB21

4.13. Saturation genome editing of BAP1 functionally classifies somatic and germline variants

AJ Waters , T Brendler-Spaeth , D Smith , V Offord , HK Tan , Y Zhao , S Obolenski , M Nielsen , R van Doorn , JE Murphy , P Gupta , CF Rowlands , H Hanson , E Delage , M Thomas , EJ Radford , SS Gerety , C Turnbull , JRB Perry , ME Hurles , DJ Adams

Brief Summary: These authors performed exhaustive saturation genome editing (SGE) of BAP1 (BRCA1-associated protein 1), the disruption of which is linked to tumorigenesis and altered neurodevelopment. 18,108 unique variants were characterized, of which 6,196 were found to have abnormal functions. These were then used to evaluate phenotypic associations in the UK Biobank. BAP1 variants were also characterized in a large population-ascertained tumor collection,...

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ESPE Yearbook of Paediatric Endocrinology

8.3 Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man

4.13. Saturation genome editing of BAP1 functionally classifies somatic and germline variants

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