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ey0018.11-2 | New hope: Increased diagnostic yield for disease causing MC4R variants and pharmacological treatment options | ESPEYB18

11.2. Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signalling

H Israeli , O Degtjarik , F Fierro , V Chunilal , AK Gill , NJ Roth , J Botta , V Prabahar , Y Peleg , LF Chan , D Ben-Zvi , PJ McCormick , Y Niv , M Shalev-Benami

Science 2021;372(6544): 808–814 doi: https://doi.org/10.1126/science.abf7958Isreali et al. describe the molecular structure of the melanocortin 4 receptor (MC4R) complexed with its effector G protein (Gs alpha) and setmelanotide, a pharmacological agonist of MC4R.MC4R is a known key element in body weight regulation, connecting response to leptin with inhibition o...

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ESPE Yearbook of Paediatric Endocrinology

11.2. Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signalling

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