ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0020.5-11 | Basic Research | ESPEYB20

5.11. Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice

J Roa , M Ruiz-Cruz , F Ruiz-Pino , R Onieva , MJ Vazquez , MJ Sanchez-Tapia , JM Ruiz-Rodriguez , V Sobrino , A Barroso , V Heras , I Velasco , C Perdices-Lopez , C Ohlsson , MS Avendano , V Prevot , M Poutanen , L Pinilla , F Gaytan , M Tena-Sempere

Brief summary: A newly developed mouse model of congenital ablation of Dicer in kisspeptin neurons was used to identify a role for miRNAs in kisspeptin neuron activity and control of reproduction.The last few years have seen a shift in paradigm with the discovery of epigenetic mechanisms regulating GnRH neuron activity and thus puberty and reproduction. In particular, miRNAs appear to play a crucial role in the maturation and function of the hypothalamic...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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