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ey0021.11-5 | Interventions for Weight Loss: New Findings | ESPEYB21

11.5. Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor

A Regmi , E Aihara , ME Christe , G Varga , TP Beyer , X Ruan , E Beebe , LS O'Farrell , MA Bellinger , AK Austin , Y Lin , H Hu , DL Konkol , S Wojnicki , AK Holland , JL Friedrich , RA Brown , AS Estelle , HS Badger , GS Gaidosh , S Kooijman , PCN Rensen , T Coskun , MK Thomas , W Roell

Brief Summary: The study investigated how tirzepatide, a dual GIPR/GLP-1R agonist, modulates adipocyte nutrient metabolism by long-acting activation of the GIP receptor. It shows that tirzepatide enhances insulin signaling, glucose uptake, and lipid metabolism in adipocytes, contributing to improved metabolic outcomes in both fasted and fed states.Tirzepatide has recently been shown to have superior efficacy in reducing HbA1c, body weight, and serum trig...

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ESPE Yearbook of Paediatric Endocrinology

11.5. Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor

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