ey0017.5-9 | Translational Highlights | ESPEYB17
5.9. Sclerostin antibody treatment increases bone mass and normalizes circulating phosphate levels in growing Hyp mice
To read the full abstract: J Bone Miner Res. 2020;35(3):59660.In brief: Antibody treatment against the Wnt antagonizing sclerostin substantially improves FGF23 levels, serum phosphate and mechanical bone properties in a murine model of X-linked hypophosphatemic rickets, suggesting a role of sclerostin in phosphate metabolism.Commentary: Associa...
ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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