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Brief Summary: This review combined findings from human and rodent studies on the maternal factors that influence the neurodevelopmental programming of long-term adiposity. It highlights the roles of maternal nutritional status, metabolic hormones and epigenetic changes during gestation and the postnatal period on the programming of body weight in the offspring, and their impact on the development of hypothalamic, brain stem, and hedonic circuits within the central nervous sys...

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ey0019.1-2 | Basic Science and Stem Cells | ESPEYB19

1.2. Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

MC Pahl , CA Doege , KM Hodge , SH Littleton , ME Leonard , S Lu , R Rausch , JA Pippin , MC De Rosa , A Basak , JP Bradfield , RK Hammond , K Boehm , RI Berkowitz , C Lasconi , C Su , A Chesi , ME Johnson , AD Wells , BF Voight , RL Leibel , DL Cousminer , SFA Grant

Nat Commun. 2021 Nov 19;12(1):6749. doi: 10.1038/s41467-021-27001-4. PMID: 34799566.Brief Summary: The authors used RNA-seq, ATAC-seq, and promoter-focused Capture C to characterize the genetic architecture during hypothalamic differentiation. This information provides insights into mechanisms by which noncoding GWAS loci are associated with hypothalamic-regulated traits potentially mediat...

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ESPE Yearbook of Paediatric Endocrinology

11.11. Neurodevelopmental programming of adiposity: contributions to obesity risk

1.2. Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

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