ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This multi-ancestry genetic analysis including ~800,000 women, identified 1,080 signals for age at menarche, explaining 11% of trait variance.Age at menarche is a highly polygenic trait which varies widely among individuals (4-5 years)1. Recent genome wide association studies, mostly conducted in subjects of European ancestry, have identified several hundred of loci corresponding to ~ 25% of the hereditability2-5....