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ey0021.8-6 | Important for Clinical Practice | ESPEYB21

8.6. Glucose. pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring

A Galderisi , D Kariyawasam , A Stoupa , AN Quoc , G Pinto , M Viaud , S Brabant , J Beltrand , M Polak , D Samara-Boustani

Brief Summary: This study investigated daily glucose patterns in young children with classic congenital adrenal hyperplasia (CAH) and their relation with hormonal circadian rhythm.Comment: The aim of treatment in classical CAH is to provide adequate glucocorticoid and when necessary mineralocorticoid replacement to prevent adrenal crises and suppress excess adrenal androgen production. Glucocorticoids regulate glucose homeostasis, and patie...

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ey0021.7-6 | Clinical Guidance and Studies | ESPEYB21

7.6. Familial central precocious puberty due to DLK1 deficiency: novel genetic findings and relevance of serum DLK1 levels

L Montenegro , C Seraphim , F Tinano , M Piovesan , APM Canton , K McElreavey , S Brabant , NP Boris , M Magnuson , RS Carroll , UB Kaiser , J Argente , V Barrios , VN Brito , R Brauner , AC Latronico

Brief Summary: This cross-sectional study identifies two pathogenic variants in the Delta-like noncanonical notch ligand 1 ( DLK1 ) gene in a French cohort of 121 children with idiopathic central precocious puberty (CPP).DLK1 is a noncanonical ligand of the Delta Notch pathway known to be involved in adipocyte differentiation. Its hypothalamic expression suggests a potential role in coordinating reproductive and metabolic functions. Pathogenic v...

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ey0021.9-13 | Growth Problems in Cancer Survivors | ESPEYB21

9.13. GH and childhood-onset craniopharyngioma: when to initiate GH replacement therapy?

A Nguyen Quoc , K Beccaria , Briceno L Gonzalez , G Pinto , D Samara-Boustani , A Stoupa , J Beltrand , A Besancon , C Thalassinos , S Puget , T Blauwblomme , C Alapetite , S Bolle , F Doz , J Grill , C Dufour , F Bourdeaut , S Abbou , L Guerrini-Rousseau , A Leruste , S Brabant , I Cavadias , M Viaud , N Boddaert , M Polak , D Kariyawasam

Brief Summary: This retrospective, observational, single centre study compared the risk of tumor progression or recurrence in 71 patients with childhood-onset craniopharyngioma (CP) who started GH replacement therapy (GHRT) with different latency from the end of tumor treatment.GHRT latency was defined as the time from end of CP treatment (last debulking procedure or radiotherapy, or from CP diagnosis for the 5 patients without any debulking procedure or...

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ESPE Yearbook of Paediatric Endocrinology

8.6. Glucose. pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring

7.6. Familial central precocious puberty due to DLK1 deficiency: novel genetic findings and relevance of serum DLK1 levels

9.13. GH and childhood-onset craniopharyngioma: when to initiate GH replacement therapy?

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