ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Cell Metabolism 2019;30:952–962. e5.These authors report that high-fat diet (HFD) in mice induces a dynamic increase in uncoupling protein 2 (Ucp2) mRNA expression in hypothalamic microglia. Ucp2 is required for HFD-induced mitochondrial changes in hypothalamic microglia and for HFD-induced inflammation, obesity, and POMC synaptic plasticity.The brain plays a major role in the regulation of ...