ey0017.5-10 | Novel Receptor Signaling Mechanisms | ESPEYB17
S Nishimori
, MJ OMeara
, CD Castro
, H Noda
, M Cetinbas
, J da Silva Martins
, U Ayturk
, DJ Brooks
, M Bruce
, M Nagata
, W Ono
, CJ Janton
, ML Bouxsein
, M Foretz
, R Berdeaux
, RI Sadreyev
, T Gardella
, H Juppner
, HM Kronenberg
, MN Wein
To read the full abstract: J Clin Invest 2019;129:51875203.In brief: This report establishes inhibition of salt-inducible kinases as a central mechanism by which the parathyroid hormone 1 receptor (PTH1R) exerts its effects in both growth plate chondrocytes and osteoblasts/osteocytes during skeletal development, growth, and remodelling.Commentary</e...