ey0021.10-15 | New Biomarkers | ESPEYB21
H Lee
, GS Sahin
, CW Chen
, S Sonthalia
, SM Canas
, HZ Oktay
, al. et
Brief Summary: This experimental study unveiled a new link between the β-cell unfolded protein response and senescence. Deletion of the genes Atf6α or Ire1α in β-cells of non-obese diabetic (NOD) mice prior to insulitis generated a p21-driven early senescence phenotype, which altered the β-cell secretome and promoted protective M2 macrophages recruitment to pancreatic islets. M2 macrophages induced immune surveillance and removal of t...