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ey0021.11-3 | Interventions for Weight Loss: New Findings | ESPEYB21

11.3. Who benefits most from outpatient lifestyle intervention? an IMI-SOPHIA study on pediatric individuals living with overweight and obesity

N Prinz , H Pomares-Millan , A Dannemann , GN Giordano , C Joisten , A Korner , D Weghuber , S Weihrauch-Bluher , S Wiegand , RW Holl , S Lanzinger

Brief Summary: For both clinicians and patients, it is of great interest to have easily-applicable predictors to forecast weight reductions achievable by lifestyle intervention (LI). This study identified 3 distinct clusters of responses to paediatric outpatient LI. Up to 2 years after LI initiation, responses ranged from pronounced BMIz loss (in 19% of patients; median delta-BMIz: -0.61 (IQR: -0.76 to -0.49) to moderate BMIz loss (in 45%; -0.23 (-0.33 ...

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ey0015.11-7 | New Developments in Monogenic Obesity | ESPEYB15

11.7 MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

K Clément , H Biebermann , IS Farooqi , L Van der Ploeg , B Wolters , C Poitou , L Puder , F Fiedorek , K Gottesdiener , G Kleinau , N Heyder , P Scheerer , U Blume-Peytavi , I Jahnke , S Sharma , J Mokrosinski , S Wiegand , A Müller , K Weiß , K Mai , J Spranger , A Grüters , O Blankenstein , H Krude , P Kühnen

To read the full abstract: Nat Med 2018, May;24(5):551-555[Comments on 1.1, 1.5, 1.6 and 1.7] All four here presented articles have monogenic obesity as their theme. While patients with monogenic obesity are rare, these individuals bear a heavy disease burden. Furthermore, these...

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ESPE Yearbook of Paediatric Endocrinology

11.3. Who benefits most from outpatient lifestyle intervention? an IMI-SOPHIA study on pediatric individuals living with overweight and obesity

11.7 MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

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