ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

Page 1 of about 2 results

ey0018.7-9 | Basic Science | ESPEYB18

7.9. ER[alpha] signaling in GHRH/Kiss1 dual-phenotype neurons plays sex-specific roles in growth and puberty

D Garcia-Galiano , AL Cara , Z Tata , SJ Allen , MG Jr Myers , E Schipani , CF Elias

J Neurosci. 2020 Dec 2;40(49):9455–9466. 10.1523/JNEUROSCI.2069-20.2020. PMID: 33158965 https://www.jneurosci.org/content/40/49/9455.longIn brief: These authors used two transgenic mouse models to assess the direct action of estrogens and androgens on GHRH neurons to control growth, pubertal development and reprod...
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ey0021.7-11 | Basic Research | ESPEYB21

7.11. Glutamate neurotransmission from leptin receptor cells is required for typical puberty and reproductive function in female mice

Miera C Saenz de , N Bellefontaine , SJ Allen , MG Myers , CF Elias

Brief Summary: This study used chemogenetics and transgenic mouse models to show that glutamatergic neurotransmission in leptin responsive neurons in the premammillary nucleus is required for normal puberty and ovulation.Puberty and the acquisition of reproductive functions result from the reawakening of a complex neuroendocrine machinery eventually leading to the activation of GnRH secretion. Metabolic cues play a crucial role in regulating this system ...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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