ey0021.9-10 | Thyroid Issues in Cancer Survivors | ESPEYB21
MT Milano
, JA Vargo
, ED Yorke
, CM Ronckers
, LC Kremer
, SMJ Chafe
, HM van Santen
, LB Marks
, SM Bentzen
, LS Constine
, IR Vogelius
Brief Summary: This review analysed 15 original studies reporting the effects of radiation therapy (RT) on thyroid gland in childhood cancer survivors (CCS). A relationship between RT dose to the thyroid gland and risk of hypothyroidism could be extrapolated from 8/15 studies. Risk of compensated hypothyroidism increased with RT dose to the thyroid: it was 12%, 25% and 44% at 10, 20 and 30 Gy, respectively. Similarly, the risk of overt hypothyroidism was 4%, 7% and 13% at 10, ...