ISSN 1662-4009 (online)

ey0021.15-5 | New Concerns | ESPEYB21

15.5. Iatrogenic Alzheimer's disease in recipients of cadaveric pituitary-derived growth hormone

G Banerjee , SF Farmer , H Hyare , Z Jaunmuktane , S Mead , NS Ryan , JM Schott , DJ Werring , P Rudge , J. Collinge

In Brief: These authors investigated patients referred to the UK National Prion Clinic (NPC) for suspected prion diseases. They identified 8 individuals with a history of receiving treatment with cadaveric pituitary-derived growth hormone (c-hGH) and referred to, or reviewed by, the NPC between 2017 and 2022. None had a diagnosis of iatrogenic Creutzfeldt–Jakob disease (CJD) (on the basis of clinical presentation, neuroimaging and biomarkers and, in two cases, by postmort...