ESPE Yearbook of Paediatric Endocrinology

Preface: This year’s Global Health chapter focuses on improving diagnostic and therapeutic capabilities in pediatric endocrinology and diabetes in underserved populations. Understanding of variations in disease incidence and treatment practices, determining the feasibility of technology use, and working to establish clinical guidelines applicable to resource-limited settings will improve our ability to meet the needs and improve the health of those living in low and middl...

Nature 2020 Dec; 588(7836): 112–117https://go.nature.com/3go7UjOThirst is sensed by two distinct types of stimuli – osmotic and hypovolaemic. The authors show that in mice these two stimuli act via separate mechanisms and neuron types, and lead to distinct drinking behavioural responses. High blood osmolality induces osmotic thirst that drives water consumption. By contrast, hypovolaemia driv...

In this 8th edition of the Yearbook of Pediatric Endocrinology and diabetes Global Health chapter, we are happy to see increased continuity across all aspects of care especially in pediatric diabetes: from improved access to medicines to e-learning, digital health, epidemiological data specific to low- and middle-income countries and treatment protocols that meet the needs of underserved populations. From a half-full/half-empty glass perspective, we see reasons for hope....

Pediatr Diabetes. 2018 May 15. doi: 10.1111/pedi.12691There is a small but significant debate as to whether or not type 1 (T1D) and type 2 diabetes (T2D) are the same disease with albeit different course. It might therefore be prudent to include into a chapter on T1D a publication on T2D. This study aimed to describe recent medication patterns and changes in medication patterns and glycemic con...

Diabetes Care. 2021 Apr 26:dc202308. doi: 10.2337/dc20-2308. PMID: 33905344.In brief: The multicenter SEARCH for Diabetes in Youth Study assessed cognitive function in adolescents and young adults with type 1 diabetes mellitus (T1DM) (n=1095) or T2DM (n=285). Mean age was 21.6±5.1 years and mean diabetes duration 11.0±3.4 years. Having T2DM was associated wit...

Brief Summary: This multicenter, international, retrospective study evaluated fertility potential and gonadal function in 326 adolescent and young adult cancer survivors. Risk factors for impairment included hematopoietic stem cell transplantation (HCT) conditioning regimen (myeloablative conditioning, MAC vs reduced-intensity conditioning, RIC).The prevalence of gonadal hormone failure in females was 55.3% (defined as FSH >30 mIU/mL with an estradio...