ISSN 1662-4009 (online)

ey0021.10-16 | New Hopes | ESPEYB21

10.16. Non-invasive measurements of blood glucose levels by time-gating mid-infrared optoacoustic signals

N Uluc , S Glasl , F Gasparin , T Yuan , H He , D Justel , al. et

Brief Summary: This study tested a new biosensor, named depth-gated mid-infrared optoacoustic sensor (DIROS), which uses intravital mid-infrared optoacoustic signals, for accurate non-invasive measurement of glucose concentrations in blood-rich volumes of the skin. DIROS provided in-blood glucose measurements with better accuracy and sensitivity than methods that measured glucose in the interstitial fluid.Non-invasive glucose monitoring is an attractive ...

ey0020.8-12 | New Mechanisms | ESPEYB20

8.12. ZnT8 loss-of-function accelerates functional maturation of hESC-derived beta cells and resists metabolic stress in diabetes

Q Ma , Y Xiao , W Xu , M Wang , S Li , Z Yang , M Xu , T Zhang , ZN Zhang , R Hu , Q Su , F Yuan , T Xiao , X Wang , Q He , J Zhao , ZJ Chen , Z Sheng , M Chai , H Wang , W Shi , Q Deng , X Cheng , W Li

Brief summary: In this experimental study, genome editing and in vitro pancreatic differentiation of human pluripotent stem cells (SC) were used to generate ZNT8 loss-of-function (LOF) SC-β-cells. These cells showed accelerated functional maturation, increased insulin secretion and improved resistance to metabolic stress. Transplantation of ZnT8 LOF SC-β-cells into mice with preexisting diabetes significantly improved their glucose levels.<...