ISSN 1662-4009 (online)

ey0020.12-11 | Basic Research | ESPEYB20

12.11. Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1

I Gonzalez-Garcia , E Garcia-Clave , A Cebrian-Serrano , O Le Thuc , RE Contreras , Y Xu , T Gruber , SC Schriever , B Legutko , J Lintelmann , J Adamski , W Wurst , TD Muller , SC Woods , PT Pfluger , MH Tschop , A Fisette , C Garcia-Caceres

Brief summary: This basic science study in mice shows how melanocortin neurons integrate reproductive signaling with energy homeostasis. In melanocortin neurons, estradiol (E2) enhances the anorectic action of leptin. Cited1 is enriched in these neurons and its loss exacerbates diet-induced obesity in female mice. Using several specific mouse models it is demonstrated how hypothalamic Cited1, via ERα and Stat3 interactions, link the effects of E2 and leptin on food intake...

ey0021.11-15 | Adipocyte Dysfunction and Obesity Related Comorbidities | ESPEYB21

11.15. A spatiotemporal proteomic map of human adipogenesis

F Klingelhuber , S Frendo-Cumbo , M Omar-Hmeadi , L Massier , P Kakimoto , AJ Taylor , M Couchet , S Ribicic , M Wabitsch , AC Messias , A Iuso , TD Muller , M Ryden , N Mejhert , N Krahmer

Brief Summary: This study created a temporally- and spatially-resolved proteomic atlas of human adipogenesis. It highlights cell restructuring and spatial reorganization of metabolic pathways to optimize cells for lipid accumulation and identifies C19orf12 as a differentiation-induced protein that regulates lipid storage in adipocytes.This study provides a comprehensive and detailed proteomic map that captures the dynamic changes in protein abundance and...

ey0018.10-14 | (1) | ESPEYB18

10.14. Targeted pharmacological therapy restores [beta]-cell function for diabetes remission

S Sachs , A Bastidas-Ponce , S Tritschler , M Bakhti , A Bottcher , MA Sanchez-Garrido , M Tarquis-Medina , M Kleinert , K Fischer , S Jall , A Harger , E Bader , S Roscioni , S Ussar , A Feuchtinger , B Yesildag , A Neelakandhan , CB Jensen , M Cornu , B Yang , B Finan , RD Di Marchi , MH Tschop , FJ Theis , SM Hofmann , TD Muller , H Lickert

Nature Metabolism. 2020;2(2):192–209. doi: 10.1038/s42255-020-0171-3.This experimental mouse study examined whether or not dedifferentiated β cells could be reversed or targeted by pharmacological intervention for diabetes remission. They identified evidence for β-cell dedifferentiation and dysfunction which could be reversed by single and combined pharmacological approach...