ISSN 1662-4009 (online)

ey0017.6-5 | Differences/Disorders of Sex Development: Basic Research | ESPEYB17

6.5. Undifferentiated spermatogonia regulate Cyp26b1 expression through NOTCH signaling and drive germ cell differentiation

PA Parekh , TX Garcia , R Waheeb , V Jain , P Gandhi , ML Meistrich , G Shetty , MC Hofmann

To read the full abstract: FASEB J. 2019, Jul; 33: 8423–35. doi: https://www.ncbi.nlm.nih.gov/pubmed/30991836Retinoic acid (RA) is essential for the regulation of many developmental events including germ cell differentiation. In the developing testis, tight spatiotemporal control of RA levels is maintained by the enzyme CYP26B1, which inactivates RA. CYP26B1 expres...