ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Science 2018;359:1395-1399Brain development and behavior are influenced by early life experiences, such as nutrients, stress, adversity and maternal care. While we believe the epigenome is the mediator, these authors investigated whether the genome itself of individual brain cells could be changed by environmental factors. A possible mechanism relies on mo...

Brief Summary: Countries differ in their approaches to newborn screening (NBS) for congenital adrenal hyperplasia (CAH), a group of genetic disorders affecting adrenal steroidogenesis. This survey describes the protocols, approaches, and outcomes of CAH screening across different countries.Members of the International Society for Neonatal Screening were invited to complete a questionnaire in 2021. Members representing 23 screening programs from Europe, S...

J Appl Toxicol. 2021 Apr;41(4):572–586. doi: 10.1002/jat.4066. PMID: 329695In this study, pregnant dams were exposed to different types of organophosphate flame retardants (OPFRs) at a sensitive development period (from gestation to lactation). The offspring were fed either a high or a low-fat diet for 17 weeks and then underwent a battery of metabolic assessments. OPFR exposure did not alte...

Lancet Diabetes Endocrinol. 2021; 9(12):876-892. PMID: 34798068https://pubmed.ncbi.nlm.nih.gov/34798068/Brief Summary: This review summarizes the current knowledge on the epidemiology, genetic background, pathophysiology, clinical presentation, diagnosis and treatment of primary aldosteronism.This review article on primary aldosteronism (PA) describes its clinical char...

To read the full abstract: Diabetes Care. 2019 Aug;42(8):1473–1480. PMID: 31332028Maternal obesity and gestational diabetes (GDM) increase the risk of offspring developing childhood obesity and type 2 diabetes. The underlying mechanisms and possible neuronal pathways are unknown but might involve changes in the hypothalamic structure and function. Novel non-invasive imaging te...

To read the full abstract: J Pediatr Hematol Oncol. 2020;10.1097/MPH.0000000000001766. doi:10.1097/MPH.0000000000001766 [published online ahead of print, 2020 Feb 28]. taftkamalden@um.edu.myChildhood cancer survivors (CCS) have a markedly increased incidence of early cardiovascular disease (CVD). Changes in retinal vessel diameter are associa...

In Brief This systematic review collated evidence from prospective cohort studies (PCS) with at least 6 months follow-up and randomized clinical trials (RCTs) to assess the influence of 100% fruit juice on body weight in children and adults. 100% fruit juice intake was associated with higher BMI gain among children and with higher weight gain in adults.In children, 17 PCS (total 45,851 children) and no RCTs were identified. Each additional serving per da...

Brief Summary: This paper discusses the potential use of artificial intelligence (AI) in neonatology for clinical practice and research. The authors highlight the importance of multi-stakeholder involvement, and the need for well designed protocols to not only test outcomes but also to address the ethical issues involved and usability, bias, transparency and acceptability.We have been using AI since the 1950s when automated ECG interpretations became ava...

To read the full abstract: JAMA Netw Open. 2019;2:e1912902.Air pollution has recently been associated with maternal thyroxine levels during mid gestation in a large single cohort study [1]. No data exist so far on the association of exposure to specific markers of residential air pollution during the first trimester, when neurodevelopment of the embryo is exclusively dependent on transplacental passage of maternal thyroxine.<p class="abstext...

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