ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This research identifies a role for SEMA6A in puberty onset by regulating median eminence vascular permeability.The authors elegantly use murine transgenics of Sema6a -/- combined with cell biology, biochemical assays and human genetics to identify a previously unknown role for Sema6a in regulating vascular permeability of endothelial cells within the median eminence (ME) to maintain neuroendocrine homeostasis. The role of SEMA6A ...