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3.14. Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors

Gibson Todd M , Karyadi Danielle M , Hartley Stephen W , Arnold Michael A , de Gonzalez Amy Berrington , Conces Miriam R , Howell Rebecca M , Kapoor Vidushi , Leisenring Wendy M , Neglia Joseph P , Sampson Joshua N , Turcotte Lucie M , Chanock Stephen J , Armstrong Gregory T , Morton Lindsay M

Brief Summary: This study explored the combined effect of genetic predisposition and radiation exposure on the risk of developing subsequent cancers in survivors of childhood cancer. It included genotype data from 11,220 5-year survivors and focused on six subsequent cancer types: basal cell carcinoma (BCC), breast cancer, thyroid cancer, squamous cell carcinoma (SCC), melanoma, and colorectal cancer. Polygenic risk scores (PRS) were derived from genome-wide association studie...

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ESPE Yearbook of Paediatric Endocrinology

3.14. Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors

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