ISSN 1662-4009 (online)

ey0021.1-6 | Novel Genes | ESPEYB21

1.6. Knockout mice with pituitary malformations help identify human cases of hypopituitarism

Martinez-Mayer J. , Brinkmeier M.L. , O'Connell S.P. , Ukagwu A. , Marti M.A. , Miras M.

Brief Summary: This elegant study analysed a phenotype-driven screen for developmental lethal mouse genes to identify candidate genes that drive hypothalamo-pituitary phenotypes.The authors used a publicly-available phenotype-driven screen, performed by the mouse models phenotyping facility at the DMDD Wellcome Sanger Institute, to identify key genes important in pituitary development. High-Resolution Episcopic Microscopy (HREM) from 209 knockout lines w...