ISSN 1662-4009 (online)

ey0021.4-10 | New Mechanisms | ESPEYB21

4.10. WIP1 is a novel specific target for growth hormone action

T Apaydin , S Zonis , C Zhou , CW Valencia , R Barrett , GJ Strous , JA Mol , V Chesnokova , S Melmed

Brief Summary: This study assessed the effect of growth hormone (GH) on WIP1 (wild-type p53-inducible phosphatase 1), a key mediator of the DNA damage response (DDR). GH suppressed DDR by inducing WIP1, which dephosphorylates and inactivates ATM (ataxia-telangiectasia mutated) kinase and its downstream effectors (such as CHK2, p53 and H2AX), leading to the accumulation of unrepaired DNA, which can potentially contribute to tumorigenesis.This elegant stud...