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7.14. Patterns of aging biomarkers, mortality, and damaging mutations illuminate the beginning of aging and causes of early-life mortality

ED Kinzina , DI Podolskiy , SE Dmitriev , VN Gladyshev

To read the full abstract: Cell Reports vol. 29,13 (2019): 42764284.e3. doi: https://www.sciencedirect.com/science/article/pii/S221112471931589X?via%3DihubThis study identifies that aging starts very early in life and is best defined by molecular damage rather than mortality. Clinically, aging is classically defined ...

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ey0021.15-16 | New Paradigms | ESPEYB21

15.16. Causality-enriched epigenetic age uncouples damage and adaptation

K Ying , H Liu , AE Tarkhov , MC Sadler , AT Lu , M Moqri , S Horvath , Z Kutalik , X Shen , VN. Gladyshev

In Brief: The authors harness large-scale genetic and DNA methylation datasets in an epigenome-wide Mendelian randomization approach, to identify CpG sites that appear to be causally related to aging-related traits. These sites are collated to produce 2 epigenetic clocks: DamAge has adverse impacts on age-related outcomes, including mortality. AdaptAge appears to confer beneficial adaptations.Steve Horvath and others originally described various epigenet...

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ESPE Yearbook of Paediatric Endocrinology

7.14. Patterns of aging biomarkers, mortality, and damaging mutations illuminate the beginning of aging and causes of early-life mortality

15.16. Causality-enriched epigenetic age uncouples damage and adaptation

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