ISSN 1662-4009 (online)

ey0016.1-6 | New Mechanisms | ESPEYB16

1.6. Regulation of feeding by somatostatin neurons in the tuberal nucleus

SX Luo , J Huang , Q Li , H Mohammad , CY Lee , K Krishna , AM Kok , YL Tan , JY Lim , H Li , LY Yeow , J Sun , M He , J Grandjean , S Sajikumar , W Han , Y Fu

To read the full abstract: Science 2018;361:76–81.The tuberal nucleus (TN) is a hypothalamic region which is well described in humans but remains poorly defined in rodents. In this paper, the authors demonstrated by specific and sophisticated techniques the role of somatostatin expressing TN (TNSST) neurons in the control of food intake in mice. Interestingly, their resul...

ey0016.15-11 | (1) | ESPEYB16

15.11. A neural circuit for gut-Induced reward

W Han , LA Tellez , MH Perkins , IO Perez , T Qu , J Ferreira , TL Ferreira , D Quinn , ZW Liu , XB Gao , MM Kaelberer , DV Bohorquez , SJ Shammah-Lagnado , G de Lartigue , IE de Araujo

To read the full abstract: Cell. 2018 Oct 18;175(3):665–678.e23.This article reports a critical role for the vagal gut-to-brain axis in motivation and reward amongst the sensory cells of the right vagal nerve. Optogenetic stimulation of the mouse vagal gut-to-brain axis produced reward behaviors. Stimulation of gut-innervating vagal sensory neurons recapped the hallmark effects of s...