ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Int J Radiat Oncol Biol Phys. 2019 Jun 1;104(2):415–424. inskippeter@gmail.comChildhood cancer survivors (CCSs) are at increased risk to develop thyroid disease, in particular hypothyroidism, nodular disease and thyroid cancer. Hyperthyroidism is less common but may occur after ionizing radiation exposure, even if the causative mechanisms are not completely clarified....

Brief summary: This study evaluated the ability of genetic risk scores to predict severe obesity in adult survivors of childhood cancer. Data from 2548 survivors of European ancestry from the St. Jude Lifetime Cohort Study was analyzed and findings were validated in 6064 survivors from the Childhood Cancer Survivor Study. Survivors with higher genetic risk scores had significantly higher odds of severe obesity. Adding genetic risk scores to prediction models that included canc...