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To read the full abstract: J Bone Miner Res 2019;34(8):13871392.In brief: Cell tracing of the growth plate chondrocytes most adjacent to the perichondrium demonstrate that they transit into the metaphysis and contribute to the pool osteoblasts and reticular stromal cells of the bone marrow during growth in young mice.Commentary: Borderline chondrocytes are the growth plate chondrocytes located as a ...

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ey0017.5-10 | Novel Receptor Signaling Mechanisms | ESPEYB17

5.10. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodelling

S Nishimori , MJ O’Meara , CD Castro , H Noda , M Cetinbas , J da Silva Martins , U Ayturk , DJ Brooks , M Bruce , M Nagata , W Ono , CJ Janton , ML Bouxsein , M Foretz , R Berdeaux , RI Sadreyev , T Gardella , H Juppner , HM Kronenberg , MN Wein

To read the full abstract: J Clin Invest 2019;129:51875203.In brief: This report establishes inhibition of salt-inducible kinases as a central mechanism by which the parathyroid hormone 1 receptor (PTH1R) exerts its effects in both growth plate chondrocytes and osteoblasts/osteocytes during skeletal development, growth, and remodelling.Commentary</e...

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ESPE Yearbook of Paediatric Endocrinology

5.14. Growth plate borderline chondrocytes behave as transient mesenchymal precursor cells

5.10. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodelling

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