ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

Page 1 of about 1 results

ey0021.11-14 | Adipocyte Dysfunction and Obesity Related Comorbidities | ESPEYB21

11.14. Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation

W Xia , P Veeragandham , Y Cao , Y Yayun Xu , TE Rhyne , J Qian , Hung Chao-Wei , P CHZhao , Y Jones , H Hui Gao , C Liddle , RT Yu , M Downes , RM Evans , M Ryden , M Wabitsch , Z Wang , H Hakozaki , J Schoneberg , SM Reilly , J Huang , AR Saltiel

Brief Summary: This study shows that obesity induces mitochondrial fragmentation and reduces oxidative capacity in white adipocytes through the activation of the small GTPase RalA. Targeted deletion of RalA in these cells prevents mitochondrial fragmentation, improves energy expenditure, and protects against obesity-induced metabolic dysfunctions, highlighting the critical role of RalA in obesity-related mitochondrial and metabolic abnormalities.Previous...
0 shares

Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
© Bioscientifica 2024 | Privacy policy | Cookie settings

BiosciAbstracts

Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.

Find out more