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ey0017.11-7 | Body Weight and Appetite/Energy Regulation | ESPEYB17

11.7. Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk

RJ Perry , K Lyu , A Rabin-Court , J Dong , X Li , Y Yang , H Qing , A Wang , X Yang , GI Shulman

To read the full abstract: J Clin Invest 2020;130(4):200116.In this study, Perry et al used their well-established animal model of fasted rats to unravel how feeding induces hyperthermia and energy expenditure.They showed that intracerebroventricular injection of leptin normalized fasting induced low plasma epinephrine and norepinephrine levels and body temperat...

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ey0021.12-11 | Metabolic Syndrome | ESPEYB21

12.11. Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction

Y Liu , JJ Jiang , SY Du , LS Mu , JJ Fan , JC Hu , Y Ye , M Ding , WY Zhou , QH Yu , YF Xia , HY Xu , YJ Shi , SW Qian , Y Tang , W Li , YJ Dang , X Dong , XY Li , CJ Xu , QQ Tang

Brief Summary: Artemisinins, compounds known for their antimalarial properties, suppress ovarian androgen synthesis by promoting degradation of cytochrome P450 11A1 (CYP11A1). Hence, they are a promising new approach for preventing and treating PCOS.Comment: Polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic anovulation, and insulin resistance, is one of the most common reproductive endocrinopathies, affecting ~8-18% of reproduc...

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ESPE Yearbook of Paediatric Endocrinology

11.7. Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk

12.11. Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction

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