ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0021.12-11 | Metabolic Syndrome | ESPEYB21

12.11. Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction

Y Liu , JJ Jiang , SY Du , LS Mu , JJ Fan , JC Hu , Y Ye , M Ding , WY Zhou , QH Yu , YF Xia , HY Xu , YJ Shi , SW Qian , Y Tang , W Li , YJ Dang , X Dong , XY Li , CJ Xu , QQ Tang

Brief Summary: Artemisinins, compounds known for their antimalarial properties, suppress ovarian androgen synthesis by promoting degradation of cytochrome P450 11A1 (CYP11A1). Hence, they are a promising new approach for preventing and treating PCOS.Comment: Polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic anovulation, and insulin resistance, is one of the most common reproductive endocrinopathies, affecting ~8-18% of reproduc...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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