ISSN 1662-4009 (online)

ey0021.3-7 | Thyroid Function - Genetic Determinants and Associations with Health and (Thyroid) Disease | ESPEYB21

3.7. The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis

Xu Yanning , Derakhshan Arash , Hysaj Ola , for the Thyroid Studies Collaboration et al

Brief Summary: This large systematic review and individual participant data (IPD) meta-analysis investigated the association between serum TSH and FT4 concentrations and the risk of cardiovascular disease (CVD) events (coronary heart disease, stroke, and heart failure) and all-cause mortality. It included data from 134,346 participants, with a median age of 59 years (range 18-106) and a median follow-up of 11.5 years. The results indicate a J-shaped association between FT4 lev...