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ey0019.1-3 | Basic Science and Stem Cells | ESPEYB19

1.3. Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells

WK Huang , SZH Wong , SR Pather , PTT Nguyen , F Zhang , DY Zhang , Z Zhang , L Lu , W Fang , L Chen , A Fernandes , Y Su , H Song , GL Ming

Cell Stem Cell. 2021 Sep 2;28(9):1657-1670.e10. doi: 10.1016/j.stem.2021.04.006. PMID: 33961804.Brief Summary: The authors established a novel protocol to generate hypothalamic arcuate organoids from human induced pluripotent stem cells, which could be utilized to investigate the arcuate nuclei development and the underlying mechanism of arcuate nucleus-related diseases. <p class="abst...

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ey0020.2-10 | Long-Acting Growth Hormone (LAGH) | ESPEYB20

2.10. Long-acting PEGylated growth hormone in children with idiopathic short stature

X Luo , S Zhao , Y Yang , G Dong , L Chen , P Li , F Luo , C Gong , Z Xu , X Xu , H Gong , H Du , L Hou , Y Zhong , Q Shi , X Chen , X Chen , L Xu , R Cheng , C Su , Y Ma , L Xu , L Zhang , H Lu

Brief summary: This randomized, multicenter, controlled, phase II study compared the effects of high-dose (HD) once-weekly PEGylated-recombinant human growth hormone (PEG-rhGH) to low-dose (LD) and to an untreated control group of children with idiopathic short stature (ISS) over a period of 52 weeks. PEG-rhGH was effective in increasing height gain in a dose dependent manner with both doses being well tolerated during the observation period.PEG-rhGH is ...

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ESPE Yearbook of Paediatric Endocrinology

1.3. Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells

2.10. Long-acting PEGylated growth hormone in children with idiopathic short stature

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