ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0021.14-1 | Basic Biology and Molecular Mechanisms | ESPEYB21

14.1. The maintenance of oocytes in the mammalian ovary involves extreme protein longevity

Harasimov Katarina , Gorry Rebecca L. , Welp Luisa M. , Penir Sarah Mae , Horokhovskyi Yehor , Cheng Shiya , Takaoka Katsuyoshi , Stutzer Alexandra , Frombach Ann-Sophie , Tavares Ana Lisa Taylor , Raabe Monika , Haag Sara , Saha Debojit , Grewe Katharina , Schipper Vera , Rizzoli Silvio O. , Urlaub Henning , Liepe Juliane , Schuh Melina

Brief Summary:The female ovary is essential for reproduction. Oocytes are stored in it for more than a year in mice, and for more than four decades in humans. This study investigated proteostasis in oocytes and ovaries of mice by combining quantitative mass spectrometry (MS), pulseĀ–chase labelling, single-cell RNA-seq and nanoscale secondary ion MS (NanoSIMS). They found extraordinary stability of hundreds of proteins. Long-lived proteins were enriched in diverse cellular...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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