Abstract Search

15.16. Causality-enriched epigenetic age uncouples damage and adaptation

K Ying , H Liu , AE Tarkhov , MC Sadler , AT Lu , M Moqri , S Horvath , Z Kutalik , X Shen , VN. Gladyshev

In Brief: The authors harness large-scale genetic and DNA methylation datasets in an epigenome-wide Mendelian randomization approach, to identify CpG sites that appear to be causally related to aging-related traits. These sites are collated to produce 2 epigenetic clocks: DamAge has adverse impacts on age-related outcomes, including mortality. AdaptAge appears to confer beneficial adaptations.Steve Horvath and others originally described various epigenet...

0 shares

ey0016.11-4 | New Insights into Body Weight Regulation | ESPEYB16

11.4. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

OS Dallner , JM Marinis , YH Lu , K Birsoy , E Werner , G Fayzikhodjaeva , BD Dill , H Molina , A Moscati , Z Kutalik , P Marques-Vidal , TO Kilpelainen , N Grarup , A Linneberg , Y Zhang , R Vaughan , RJF Loos , MA Lazar , JM Friedman

To read the full abstract: Nature Medicine 2019; 25(3):507-516.This paper shows that quantitative leptin expression is controlled by redundant cis elements and trans factors that interact with the proximal promoter together with a long noncoding RNA.Friedmans research group discovered the adipocyte hormone leptin more than 20 years ago. They identified loss o...

0 shares

ESPE Yearbook of Paediatric Endocrinology

15.16. Causality-enriched epigenetic age uncouples damage and adaptation

11.4. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

BiosciAbstracts