ESPE Yearbook of Paediatric Endocrinology

In Brief: These authors studied liver-specific SIRT2 knockout mice to examine how loss of hepatocyte SIRT2 (Sirtuin 2) prevents bone loss in aged mice. Hepatocyte SIRT2 deficiency led to upregulation of Leucine rich α2 glycoprotein (LRG1) in hepatocyte-derived small extracellular vesicles (sEVs) which inhibited osteoclastogenesis in bone marrow.Commentary: Liver-bone communication has been implicated in bone homeostasis. P...

Brief Summary: The authors propose a simplified definition of pediatric metabolic syndrome (MetS) for children aged 6-17 years. This uses static cut-offs, enabling easier and quicker assessment in clinical practice, and allowing comparison of MetS prevalence across different pediatric populations.Comment: There is no consensus on the definition of pediatric metabolic syndrome (MetS). Existing pediatric MetS definitions involve age-, sex- or height-specif...