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ey0019.3-15 | Paediatric thyroid cancer | ESPEYB19

3.15. Association between radioactive iodine treatment for pediatric and young adulthood differentiated thyroid cancer and risk of second primary malignancies

E Pasqual , S Schonfeld , LM Morton , D Villoing , C Lee , de Gonzalez A Berrington , CM Kitahara

J Clin Oncol. 2022 May 1;40(13):1439-1449. doi: 10.1200/JCO.21.01841. Epub 2022 Jan 19. PMID: 35044839Brief Summary: This retrospective study showed that children and young adults (< 45 years) treated with radioactive iodine (RAI) for primary Differentiated Thyroid Cancer (DTC) have increased risks for leukemia and solid cancers, particularly beyond 20 years after treatment.<p class="abs...

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ey0021.3-14 | Thyroid Cancer | ESPEYB21

3.14. Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors

Gibson Todd M , Karyadi Danielle M , Hartley Stephen W , Arnold Michael A , de Gonzalez Amy Berrington , Conces Miriam R , Howell Rebecca M , Kapoor Vidushi , Leisenring Wendy M , Neglia Joseph P , Sampson Joshua N , Turcotte Lucie M , Chanock Stephen J , Armstrong Gregory T , Morton Lindsay M

Brief Summary: This study explored the combined effect of genetic predisposition and radiation exposure on the risk of developing subsequent cancers in survivors of childhood cancer. It included genotype data from 11,220 5-year survivors and focused on six subsequent cancer types: basal cell carcinoma (BCC), breast cancer, thyroid cancer, squamous cell carcinoma (SCC), melanoma, and colorectal cancer. Polygenic risk scores (PRS) were derived from genome-wide association studie...

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ESPE Yearbook of Paediatric Endocrinology

3.15. Association between radioactive iodine treatment for pediatric and young adulthood differentiated thyroid cancer and risk of second primary malignancies

3.14. Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors

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