ey0021.1-1 | New Mechanisms | ESPEYB21
Lettieri A.
, Oleari R.
, van den Munkhof M.H.
, van Battum E.Y.
, Verhagen M.G.
, Tacconi C.
Brief Summary: This research identifies a role for SEMA6A in puberty onset by regulating median eminence vascular permeability.The authors elegantly use murine transgenics of Sema6a -/- combined with cell biology, biochemical assays and human genetics to identify a previously unknown role for Sema6a in regulating vascular permeability of endothelial cells within the median eminence (ME) to maintain neuroendocrine homeostasis. The role of SEMA6A ...