ESPE Yearbook of Paediatric Endocrinology

iScience. 2021 Oct 11;24(11):103257. PMID: 34761181, doi: 10.1016/j.isci.2021.103257.Brief Summary: The authors explored the relationship between sex hormones and lipids in pre-pubertal children, young post-pubertal cisgender men and women, and transgender adolescents on gender affirming hormone (GAH) tre...

gaetano.riemma@unicampania.it Cancers 2021, 13, 6331. PMID: 34944951.Brief Summary: This systematic review and meta-analysis examined the value of anti-Müllerian hormone (AMH) to predict premature ovarian failure (POI) in childhood cancer survivors (CCSs), compared to the general population.The potential toxic effect of alkylating agents and body irradiation on female...

Lancet. 2021 Nov 13;398(10313):1837-1850. https://pubmed.ncbi.nlm.nih.gov/34774146/Brief Summary: This review summarizes key aspects of type 1 diabetes (T1D), such as epidemiology, pathogenesis, risk factors and management. While reviewing and discussing these topics, the central theme of the review is the burden of T1D and the challenges encountered in its daily management in low- and midd...

jcmbanya@yahoo.co.uk Pediatr Diabetes 2022; 23: 33–37. doi: 10.1111/pedi.13294Brief Summary: Despite provision of free insulin by the Changing Diabetes in Children (CDiC) program, mortality remains high in children and adolescents with type 1 diabetes (T1D) in Cameroon, in particular in rural settings and in families with no formal education.<p cl...

To read the full abstract: J Bone Miner Res. 2020 Apr 24. doi: https://pubmed.ncbi.nlm.nih.gov/32329913/In brief: Hematopoietic stem cell transplantation remains the only curative treatment in children with severe osteopetrosis. According to this study, increased serum calcium and phosphate serve as good markers of successful engraftment, which leads to significant but incomplete n...

To read the full abstract: FASEB J. 2019, Jul; 33: 8423–35. doi: https://www.ncbi.nlm.nih.gov/pubmed/30991836Retinoic acid (RA) is essential for the regulation of many developmental events including germ cell differentiation. In the developing testis, tight spatiotemporal control of RA levels is maintained by the enzyme CYP26B1, which inactivates RA. CYP26B1 expres...

To read the full abstract: J Sex Med. 2020, Apr; 17: 570–84. doi: https://www.ncbi.nlm.nih.gov/pubmed/32111534This position statement provides an update for health-care professionals on recommended basic principles for care of transgender people, including male, female and nonbinary. It uses a developmental approach to describe the best care for prepubescent, pubescent and adolescen...

To read the full abstract: PLoS One. 2019;14(12):e0226262. geraldine.delbes@iaf.inrs.caMale childhood cancer survivors (CCS) show reduced fertility, mostly due to low sperm count. The links between DNA damage caused by cancer and its treatment, pubertal stage at diagnosis and future infertility are still unclear. This Canadian pilot study analysed reproductive parameters and sperm characteristics...

To read the full abstract: JAMA Pediatr. 2020;174(4):e195881. doi: 10.1001/jamapediatrics.2019.5881• The authors evaluated the change in pubertal onset in healthy girls around the world based on age at thelarche.• Overall, the age at thelarche decreased 0.24 years per decade from 1977 to 2013.• This decrease seems to reflect a worldwide trend....

To read the full abstract: Nature 2020; 581, 434–443The Genome Aggregation Database (gnomAD) Consortium https://gnomad.broadinstitute.org compiled data on ˜125,000 exomes and ~15,000 whole genomes from populations around the world. This is one of seven articles (also see Refs 1–6) describing their initial discoveries, showing the power of this vast dataset, and presenting a more comp...