ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Nat Med. 2017 Dec; 23(12): 1444–1453This study highlights the importance of asprosin in the regulation of appetite. This peptide hormone was first described by Romere et al. in 2016 (1), who reported 2 patients with neonatal progeroid syndrome (NPS) due to truncating heterozygous mutations in the fibrillin-gene (FBN1). The FBN1 gene encodes profibrillin wh...

Brief summary: In this experimental study, pancreas-derived mesenchymal stem cells (PMSCs) were implanted into the kidney capsule of mice with streptozotocin (STZ)-induced diabetes. PMSCs led to increased levels of IL-6 in T-helper 1 and T-helper 17 cells, which transiently activated tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ), which in turn decreased levels of interleukin-17. This was associated with exocrine pancreas regeneration and rescue of ...

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To read the full abstract: Pediatr Nephrol. 2017;32:949-964This is a comprehensive review on growth and sexual maturation during puberty in children with chronic kidney disease (CKD). Despite attention to preserve growth potential during pre-puberty and the availability of recombinant human growth hormone (rhGH), the achievement of normal pubertal height gain remains a challenge in CKD. In pr...

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Brief summary: This review uses an evolutionary approach to provide an interesting discussion on a proposed period of development called ‘emerging adulthood’. The authors explain that it can be seen not only as a sociological transition period but also as a biological life-history phase.The central theme of this review is ‘emerging adulthood’, which is the concept that an additional 4-6-year pre-adult period should be included in mode...

To read the full abstract: Nat Metab 2019;1:1202–1208.Metformin has become a mainstay in the treatment of T2DM in over six decades of clinical use and is today one of the world’s most commonly prescribed drugs. Anti-diabetic properties of metformin rely on an inhibition of hepatic glucose output through AMPK-dependent, but also AMPK-independent effects (reviewed in (1)). Neverthel...

J Cancer Surviv. 2021; 15: 259–272. https://pubmed.ncbi.nlm.nih.gov/32844376/Long-term treatment effects are possible reasons for reduced fertility and adverse pregnancy outcomes in childhood cancer survivors (CCS) (1). This observational study reports perinatal and health outcomes of offspring born to CCS using assisted reproductive technologies (ART). CCS were almost 2-fold more like...

To read the full abstract: Int J Radiat Oncol Biol Phys. 2019 Jun 1;104(2):415–424. inskippeter@gmail.comChildhood cancer survivors (CCSs) are at increased risk to develop thyroid disease, in particular hypothyroidism, nodular disease and thyroid cancer. Hyperthyroidism is less common but may occur after ionizing radiation exposure, even if the causative mechanisms are not completely clarified....

To read the full abstract: Endocrine. 2018 Jul; 61(1):76Hematopoietic stem cell transplantation (HSCT) is a curative treatment for life-threatening malignancies. However, late HSCT adverse effects cause substantial morbidity among long-term survivors. Metabolic complications, such as diabetes mellitus and hyperlipidemia, are the major late effects of pediatric HSCT, but the pathogenesis ...