ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Endocrinology, April 2020, 161(4):1–18The aim of this study was to examine the role of growth hormone (GH) on gut microbiome and intestinal phenotype by using two animal models characterized by an opposite GH status: GH gene-disrupted (GH-/-) mice, characterized by GH deficiency; and bovine GH transgenic (bGH) mice with chronic GH excess. The abundance of common bacterial genera, such as Parasutterella, Ruminococc...

Elife. 2021 Sep 8;10:e69765. doi: 10.7554/eLife.69765. PMID: 34494548. https://elifesciences.org/articles/69765Brief Summary: Using a database for arcuate nucleus transcripts, this study identifies Nhlhl2 as a key regulator of the Kiss1 gene in male mice.The timing of puberty onset is i...

J Clin Endocrinol Metab. 2022; 107(3): 801-812. PMID: 34653252 https://pubmed.ncbi.nlm.nih.gov/34653252/Brief Summary: This clinical trial evaluated the safety and efficacy of crinecerfont, a CRF1R antagonist, in suppressing adrenal androgen secretion in adult patients with classic congenital adrenal hyperplasia (CAH) during a treatment period of 14 days.Class...

J Clin Endocrinol Metab. 2021; 106(11): e4666-e4679. PMID: 34146101https://pubmed.ncbi.nlm.nih.gov/34146101/Brief Summary: These clinical trials evaluated the safety and efficacy of tildacerfront, a CRF1R antagonist, in suppressing adrenal androgen secretion in adult patients with classical Congenital adrenal hyperplasia (CAH) during a treatment period of 12 weeks.<p class="abs...

To read the full abstract: Proc Natl Acad Sci U S A. 2019, Dec 3; 116: 24480-5. doi: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900519/pdf/pnas.201909367.pdfIn a large sample of 317 US American transgender children aged 3–12 years, the authors compared gender outcomes of transgender children with cisgender peers. They also assessed whether the time ...

To read the full abstract: Front. Endocrinol. 2020 11:142. doi: 10.3389/fendo.2020.00142• A delayed transition from the infancy to the childhood growth stage contributes to sub-optimal growth outcomes.• Using a novel method to assess the timing of infancy-childhood transition (quantification of patterns of adjacent monthly weight-for-age z-score (WAZ) deviation correlations), th...

To read the full abstract: J Clin Endocrinol Metab. 2018;103(4):1330-1341Glucocorticoids exert an inverted U-shaped influence on human cognition, particularly on acquiring and consolidating memory (25), whereas androgens have an overall beneficial effect on cognitive control, verbal memory, and spatial cognition in humans (26). Although previous studies in patients with CAH have con...

To read the full abstract: Diabetes Care. 2018;41:303-310One of the major short term complications of T1DM is the imminent risk of hypoglycemia during insulin treatment. In addition and importantly, long term complications of diabetes include those induced by frequent hypoglycemia, namely neurologic and developmental impairment upon frequent hypoglycemic episodes at a young age. In addition, it is de...

Int J Obes (Lond). 2021;45(1):66–76. doi: https://doi.org/10.1038/s41366-020-00673-6This study investigated the influence of MC4R variants on treatment effectiveness in a large cohort undergoing an outpatient treatment program. Carriers of MC4R loss-of-function (LoF) variants showed a lack of improvement in BMI, in contrast to non LoF carriers.As we learn th...

shane.norris@wits.ac.za Lancet 2022; 399: 172–84. doi: 10.1016/S0140-6736(21)01590-7Brief Summary: This review found that the role of nutrition on adolescent growth and development has been poorly studied. Adolescence is a nutrition-sensitive phase for growth, in which the benefits of good nutrition extend to many other physiological sys...