ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: PLoS Medicine vol. 16,12 e1002986. 2 Dec. 2019. doi: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002986This large scale population-based cohort study identifies a slightly higher risk for adult fracture in men who had later puberty. The pubertal period plays a key role...

p.froguel@imperial.ac.uk Diabetes 2022;71:694–705https://doi.org/10.2337/db21-0373Brief Summary: In this observational cross-sectional study in 128 randomly selected young obese adults (BMI 37.2±0.3 kg/m2; age 18.4±0.3 years) from the Severe Obesity in Pakistani Population (SOPP), screening by whole-exome analysis found 3% had ...

Brief summary: This retrospective longitudinal study included 5698 patients with multiple height measurements since birth to the near-adult age. The aim was to define different growth patterns of children from birth to 18 years corrected for gestational age, sex and auxological status at birth in order to early identify children at risk for adult short stature. Adult height was significantly reduced in preterm and/or in small-for-gestational-age (SGA) children, with no sex dif...

To read the full abstract: Pediatrics. 2020, Mar; 145. doi: https://pediatrics.aappublications.org/content/pediatrics/145/3/e20190741.full.pdfCardiovascular health of transgender people was a hot topic in the transgender literature last year, triggered by previous findings that these individuals could have elevated risks for cardiovascular diseases b...

Brief summary: The AMOS2 study is a randomized, open label, multicentre trial. It reports 2-year BMI changes in n=25 adolescents (age 13–16 years) after metabolic and bariatric surgery (MBS) (Roux-en-Y gastric bypass n=23, sleeve gastrectomy n=2) compared to n=23 adolescents who received intensive non-surgical treatment. After 2 years, BMI change was −12.6 kg/m2 in the MBS group compared to only −0.2 kg/m2</s...

To read the full abstract: J Clin Endocrinol Metab. 2019 Mar 28. pii: jc.2018-02559. [Epub ahead of print]This meta-analysis aimed to define the effect of mild to moderate iodine deficiency on child neurological outcome. The authors combined data from three large prospective national studies on 6180 mother child pairs with available urinary iodine and creatinine concentrations in pregnan...

Brief summary: This review provides an update on the possible actions of metformin beyond glucose regulation in the liver. It summarizes recent findings regarding its action in the gastrointestinal tract, on gut microbiota and tissue-resident immune cells and thereby gives insight into studies addressing its immune-modulating and anti-inflammatory effects for possible use as treatment against inflammation- and age-related diseases, as well as cancer. Current knowledge of metfo...

To read the full abstract: Nature Medicine. 2019;25(11):1733–8. PMID 31700171.These authors sequenced the gene for melanocortin-2 receptor accessory protein (MRAP2 ) in 9418 blood DNA samples from several population studies. They detected 23 rare heterozygous variants, which were significantly associated with an increased risk of obesity (OR 3.8 in children and 2.9 in adults)....

Diabetes Care. 2022 Apr 1;45(4):871-879. https://pubmed.ncbi.nlm.nih.gov/35147706/Brief Summary: This Finnish cross-sectional register-based study of 6015 youth with new onset type 1 diabetes (T1D) explored potential differences in clinical, autoimmune and genetic characteristics across three age groups: <7, 7-12 and ≥13 years. Significant differences emerged primarily between the...

To read the full abstract: Eur J Neurosci. 2019, Oct; 50: 3269-81. doi: https://onlinelibrary.wiley.com/doi/full/10.1111/ejn.14420This longitudinal study investigated the effects of cross-sex hormone treatment on brain morphology in 40 transgender men and 24 transgender women with gender dysphoria. The MRI changes were related to body perception as assessed by questionnaire...