ISSN 1662-4009 (online)

ey0017.8-20 | Reviews | ESPEYB17

8.20 11-Oxygenated androgens in health and disease

AF Turcu , J Rege , RJ Auchus , WE Rainey

To read the full abstract: Nat Rev Endocrinol. 2020; 16(5): 284–296. PMID: 32203405.The adrenal gland is the primary source of 11-oxygenated 19-carbon steroids, also termed 11-oxyandrogens, which have several roles in human physiology and disease. These include 11β-hydroxyandrostenedione (11OHA4), 11-Ketotestosterone, (downstream metabolite of 11OHA4, mostly produced in peripheral...

ey0015.7-3 | Adolescence and behavior | ESPEYB15

7.3 Age at Menarche, Depression, and Antisocial Behavior in Adulthood

J Mendle , RM Ryan , KMP McKone

To read the full abstract: Pediatrics. 2018 Jan;141(1)Changes in biology, appearance, self-perception, behavior, and emotion make puberty one of the most pivotal phases in life. Although puberty presents challenges for all adolescents, girls who mature early are particularly vulnerable. Early pubertal timing in girls has been reported to be associated with increased prevalence and severity of ps...

ey0020.1-7 | Congenital Hypothyroidism | ESPEYB20

1.7. Comorbidity in congenital hypothyroidism - A nationwide population-based cohort study

E Danner , J Jaaskelainen , L Niuro , H Huopio , H Niinikoski , L Viikari , J Kero , R Sund

Brief summary: Patients with congenital hypothyroidism have a higher rate of comorbidities in adult age (1). This nationwide population-based register study aimed at investigating the incidence of comorbidities present at birth or acquired during childhood in patients with congenital hypothyroidism and prescription of specific drugs (antidepressants, antipsychotics, medication for ADHS).The study analyzed data from n=438 full-term patients with ...

ey0021.8-7 | Important for Clinical Practice | ESPEYB21

8.7. Parental concerns about genital differences in children with congenital adrenal hyperplasia persist regardless of the selected intervention

J Alderson , M Thornton , M Skae , J Jones , N Nicoll , D Harcourt , M Woodward , EC Crowne

Brief Summary: This qualitative study investigated parental communication with their daughters regarding variation in clitoral size related to severity of classical congenital adrenal hyprplasia (CAH). The authors conducted semi-structured in-person interviews with 24 parents of children with a specific genital difference, without direct exploration of parental values regarding the clitoris or the application of adequate psychosocial care.Comment: CAH du...

ey0020.14-6 | Section | ESPEYB20

14.6. Outcomes of pubertal development in girls as a function of pubertal onset age

A German , M Shmoish , J Belsky , Z Hochberg

Brief summary: This prospective study, including 380 American girls followed from birth to age 15.5 years between 1991 and 2006, showed the predictive nature of age at onset of puberty for the subsequent progression and duration of pubertal maturation.Ze’ev Hochberg’s scientific and clinical curiosity is an inspiration for us all. Ze’ev approached the topic of puberty using evolutionary and developmental biology principles, according to wh...

ey0019.11-11 | Weight regulation and endocrine circuits (including interventions) | ESPEYB19

11.11. The pubertal growth spurt is diminished in children with severe obesity

A Holmgren , GA Martos-Moreno , A Niklasson , J Martinez-Villanueva , J Argente , K Albertsson-Wikland

anton.holmgren@regionhalland.se Pediatr Res. 2021 Jul;90(1):184–190. doi: 10.1038/s41390-020-01234-3.Brief Summary: This observational study compared the pubertal growth spurt of children in a Spanish study group with severe early onset obesity to children in a Swedish community-based study. The authors show that childhood obesity i...

ey0016.9-2 | Metabolic and Cardiovascular Risk in Cancer Survivors | ESPEYB16

9.2. The late effects of radiation therapy on skeletal muscle morphology and progenitor cell content are influenced by diet-induced obesity and exercise training in male mice

D D'Souza , S Roubos , J Larkin , J Lloyd , R Emmons , H Chen , M De Lisio

To read the full abstract: Sci Rep. 2019 Apr 30; 9(1): 6691.In recent years, improved knowledge of the metabolic risks in childhood cancer survivors (CCS) has increasingly focused research on modifiable factors and preventive strategies (1–2). It is well known that therapeutic irradiation can cause detrimental changes in body composition, but it is still unknown whether the specific...

ey0021.8-9 | Important for Clinical Practice | ESPEYB21

8.9. Consensus statement by the French Society of Endocrinology (SFE) and French Society of Pediatric Endocrinology & Diabetology (SFEDP) for the diagnosis of Cushing's syndrome: Genetics of Cushing's syndrome

L Martinerie , J Bouligand , MO North , J Bertherat , G Assie , S Espiard

Brief Summary: This brief and concise Consensus statement by the French Society of Endocrinology (SFE) and French Society of Pediatric Endocrinology & Diabetology (SFEDP), describes a systematic review and provides recommendations for the use of genetic screening in Cushing’s syndrome (CS).Comment: The etiology of CS may involve both germline genetic alterations (detectable in leukocyte DNA) and somatic mutations (present only in tumor DNA). Two...

ey0017.6-16 | Transgender Medicine: Reviews and Position Statements | ESPEYB17

6.16. European society for sexual medicine position statement [ldquo]assessment and hormonal management in adolescent and adult trans people, with attention for sexual function and satisfaction[rdquo]

G T’Sjoen , J Arcelus , ALC De Vries , AD Fisher , TO Nieder , M Ozer , J Motmans

To read the full abstract: J Sex Med. 2020, Apr; 17: 570–84. doi: https://www.ncbi.nlm.nih.gov/pubmed/32111534This position statement provides an update for health-care professionals on recommended basic principles for care of transgender people, including male, female and nonbinary. It uses a developmental approach to describe the best care for prepubescent, pubescent and adolescen...

ey0019.5-4 | Advances in clinical practice | ESPEYB19

5.4. PTH infusion for seizures in autosomal dominant hypocalcemia type 1

A Sastre , K Valentino , FM Hannan , KE Lines , AK Gluck , M Stevenson , M Ryalls , RJ Gorrigan , D Pullen , J Buck , S Sankaranarayanan , J Allgrove , RV Thakker , EF Gevers

N Engl J Med. 2021 Jul 8;385(2):189-191.Abstract: https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/34233101/In brief: This study retrospectively analysed a cohort of patients with autosomal dominant hypocalcemia type 1 and recurrent hypocalcemic seizures treated with continuous subcutaneous PTH (1-34) infusions using insulin pumps. Compared to conventional therapy, PTH (1-34)...