ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Clin Endocrinol Metab. 2017 Jul 1;102(7):2584-2594Maternal obesity and nutrient excess in utero increase the risk of future metabolic diseases. The mechanisms underlying this process are poorly understood, but probably include genetic, epigenetic alterations and changes in fetal nutrient supply. Placenta, and particularly amniotic fluid, is the in utero ...

Diabetes Care. 2021 Apr 26:dc202308. doi: 10.2337/dc20-2308. PMID: 33905344.In brief: The multicenter SEARCH for Diabetes in Youth Study assessed cognitive function in adolescents and young adults with type 1 diabetes mellitus (T1DM) (n=1095) or T2DM (n=285). Mean age was 21.6±5.1 years and mean diabetes duration 11.0±3.4 years. Having T2DM was associated wit...

Diabetes Care. 2020 Oct;43(10):2544–2552. doi: 10.2337/dc19-2164. PMID: 32778556.In brief: This cross-sectional study compared bone mineral density (BMD), lean body mass and abdominal visceral fat between 180 individuals with T2DM, 226 with obesity, and 238 with normal weight, aged 10–23 years. The findings suggest that T2DM in youth may have a detrimental effect on bone accru...

Psychoneuroendocrinology. 2022; 137: 105604. PMID: 34971856https://pubmed.ncbi.nlm.nih.gov/34971856/Brief Summary: This study evaluated the associations between the amygdala total and sub-region volumes in relation to sex hormones – estradiol and free testosterone – as a function of age and genetic differences in androgen receptor sensitivity in 297 adolescents. It provides new kno...

To read the full abstract: Lancet Glob Health 2020;8: e134–42. doi: 10.1016/S2214-109X(19)30457-7• The results of 25OH Vit D determination from 129 studies including 21 474 participants in 23 African countries were analyzed.• Overall, a serum 25(OH)D concentration less than 30 nmol/L was found in 18.5% of the population and less than 75 nmol/l in 59.5% of the populatio...

To read the full abstract: Cell. 2018; 175(3): 695–708This paper demonstrates for the first time the existence of extracellular vesicle (EV)-mediated signaling between cell types within the adipose tissue. The results of various experiments show a network of EV-mediated exchange of cellular material in adipose tissue. This newly discovered EV trafficking in adipose tissue...

To read the full abstract: Development 2017; 144:3533-3546Endochondral ossification is the process by which the embryonic cartilaginous scaffold of most bones is gradually replaced by bone. During this process chondrocytes proliferate, undergo hypertrophy and maturation and form the growth plate, essential for bone growth. Postnatal bone growth is tightly regulated by both systemic and lo...

To read the full abstract: Diabetes Care. 2017;40:1010-1016Professor Tamberlane and co-workers investigated the rates of severe hypoglycemia in the DCCT/Epidemiology of Diabetes Interventions and Complications (EDIC) cohort after approximately 30 years of follow-up. In earlier studies, high rates of hypoglycemic episodes had been found to be associated with lower HbA1c levels and intensified insulin ...

To read the full abstract: Obes Rev. 2019 Nov;20(11):1523–1541. doi: 10.1111/obr.12923.This is a thoughtful position statement by a number of leading obesity researchers and statisticians. They draw attention to 10 errors that are common in the scientific literature: 1. Using self-reported outcomes and ‘teaching to the test’ (achieving better scores simply by repeat testing); 2. L...

To read the full abstract: Nature Medicine 2019; 25(3):507-516.This paper shows that quantitative leptin expression is controlled by redundant cis elements and trans factors that interact with the proximal promoter together with a long noncoding RNA.Friedman’s research group discovered the adipocyte hormone leptin more than 20 years ago. They identified loss o...