ISSN 1662-4009 (online)

ey0020.11-3 | Improving Access to Healthcare in Pediatric Endocrinology and Diabetes | ESPEYB20

11.3. Ten-year experience of a global and freely accessible e-Learning website for pediatric endocrinology and diabetes

SM Ng , E Kalaitzoglou , A Utari , C van Wijngaard-de Vugt , M Donaldson , JI Wolfsdorf , AM Boot , S Drop

Brief summary: The authors describe the various applications of the content of ESPE’s e-learning website that has been expanding greatly over the last 10 years. The program includes a Limited Resource Setting module that was developed in 2017 and has been translated into French, Spanish, Swahili, and Chinese.This interesting article retraces the successful development of ESPE’s e-learning program since 2012. Thanks to the tenacity and involveme...

ey0018.1-6 | Development/Ontogeny | ESPEYB18

1.6. The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus

C Huisman , YA Kim , S Jeon , B Shin , J Choi , SJ Lim , SM Youn , Y Park , K C M , S Kim , SK Lee , S Lee , JW Lee

Nat Commun. 2021 Jan 11;12(1):256. doi: 10.1038/s41467-020-20511-7. PMID: 33431871.These authors report two Mll4 mutant mouse models that exhibited dwarfism and altered development of GHRH−neurons.Inactivating mutations in KDM6A (aka UTX) or KMT2D (aka MLL4) genes result in Kabuki syndrome (KS), whose hallmarks in...

ey0019.8-8 | Clinical Trials – New Treatments | ESPEYB19

8.8. Crinecerfont lowers elevated hormone markers in adults with 21-hydroxylase deficiency congenital adrenal hyperplasia

AR Auchus , K Sarafoglou , PY Fechner , MG Vogiatzi , EA Imel , SM Davis , N Giri , J Sturgeon , E Roberts , JL Chan , RH Farber

J Clin Endocrinol Metab. 2022; 107(3): 801-812. PMID: 34653252 https://pubmed.ncbi.nlm.nih.gov/34653252/Brief Summary: This clinical trial evaluated the safety and efficacy of crinecerfont, a CRF1R antagonist, in suppressing adrenal androgen secretion in adult patients with classic congenital adrenal hyperplasia (CAH) during a treatment period of 14 days.Class...

ey0017.2-14 | Gestational Diabetes Mellitus: Neonatal and Long-term Consequences | ESPEYB17

2.14. Gestational diabetes adversely affects pancreatic islet architecture and function in the male rat offspring

P Agarwal , N Brar , TS Morriseau , SM Kereliuk , MA Fonseca , LK Cole , A Jha , B Xiang , KL Hunt , N Seshadri , GM Hatch , CA Doucette , VW Dolinsky

To read the full abstract: Endocrinology. 2019 Aug 1;160(8):1907–1925. PMID: 31237608Gestational diabetes (GDM) is associated with impaired beta-cell function in the offspring and this leads to increased risk of type 2 diabetes mellitus (1). However, the underlying mechanisms are not well understood. GDM exposure may alter islet gene expression and function in the fetus. Impai...

ey0016.1-4 | New Mechanisms | ESPEYB16

1.4. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones

CB Herber , WC Krause , L Wang , JR Bayrer , A Li , M Schmitz , A Fields , B Ford , Z Zhang , MS Reid , DK Nomura , RA Nissenson , SM Correa , HA Ingraham

To read the full abstract: Nat Commun 2019;10:163.Central estrogen signaling via estrogen receptor alpha (ERα) coordinates energy expenditure, reproduction and, in concert with peripheral estrogen, impacts skeletal homeostasis. Here, the authors showed that eliminating ERα in kisspeptin arcuate nucleus neurons resulted in high bone mass phenotype in female mice only.<p clas...

ey0015.5-9 | Life-long skeletal consequences of delayed puberty | ESPEYB15

5.9 Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood

DL Cousminer , JA Mitchell , A Chesi , SM Roy , HJ Kalkwarf , JM Lappe , V Gilsanz , SE Oberfield , JA Shepherd , A Kelly , SE McCormack , BF Voight , BS Zemel , SF Grant

To read the full abstract: J Bone Miner Res 2018;33:430-436Bone mass increases dramatically during puberty. The process of sexual maturation is therefore likely to impact lifelong bone health. Bone mineral density (BMD) tracks throughout life and later age at menarche is associated with increased osteoporosis risk in women, possibly because of combined effects of later menarche and lower peak bone ma...

ey0015.6-3 | Important for clinical practice | ESPEYB15

6.3 Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline

WC Hembree , PT Cohen-Kettenis , L Gooren , SE Hannema , WJ Meyer , MH Murad , SM Rosenthal , JD Safer , V Tangpricha , GG T’Sjoen

To read the full abstract: J Clin Endocrinol Metab 2017 Nov 1;102(11):3869-3903This Endocrine Society endorsed paper is an update of the 2009 version, also published in JCEM, with clinical guidelines for endocrine management of patients with GD. The major focus is on adult patients but a large part is also focusing on children and adolescents with GD, contributed by co-authors with pediatric endo...

ey0015.10-23 | Therapy and interventions | ESPEYB15

10.23 Effect of financial incentives on glucose monitoring adherence and glycemic control among adolescents and young adults with T1DM: a randomized clinical trial

CA Wong , VA Miller , K Murphy , D Small , CA Ford , SM Willi , J Feingold , A Morris , YP Ha , J Zhu , W Wang , MS Patel

To read the full abstract: JAMA Pediatr. 2017;171:1176-1183Adolescence is certainly the most difficult age for reaching T1DM treatment and HbA1c goals. In this age group, most patients have deteriorated metabolic control, and higher risk for acute complications, such as severe hypoglycemia and DKA. Getting into therapeutic contact is very hard in this period of life for diabetes teams ...

ey0015.13-1 | How does paediatric endocrinology and diabetes fit in the global initiatives? | ESPEYB15

13.1 Supporting Global Health at the Pediatric Department Level: Why and How

MB Pitt , MA Moore , CC John , M Batra , SM Butteris , GE Airewele , PS Suchdev , MC Steinhoff , on behalf of the American Board of Pediatrics Global Health Task Force

To read the full abstract: Pediatrics 2017; 139(6)This article provides guidelines for leaders in academic institutions in high-income countries who wish to develop a global health stream in their department. We should not forget that over the last 25 years, major changes in our world have decreased the distances between nations. Pediatric residents who train in high income countries are increas...

ey0019.15-5 | Diabetes | ESPEYB19

15.5. Trends in prevalence of type 1 and type 2 diabetes in children and adolescents in the US, 2001-2017

JM Lawrence , J Divers , S Isom , S Saydah , G Imperatore , C Pihoker , SM Marcovina , EJ Mayer-Davis , RF Hamman , L Dolan , D Dabelea , DJ Pettitt , AD Liese , Group SfDiYS

JAMA. 2021;326(8):717-27. doi: 10.1001/jama.2021.11165.PubMed ID: 34427600Brief summary: This large repeated cross-sectional study identified all individuals aged <20 years with physician-diagnosed diabetes in 6 areas in the US in 2001, 2009, and 2017. Over these 16 years, the prevalence of Type 1 diabetes (T1D) increased by 45% (95% CI, 40%–50%) and the prevalence of Type 2 diabetes...