ESPE Yearbook of Paediatric Endocrinology

Diabetologia. 2021 Jun;64(6):1342–1347. 10.1007/s00125-021-05428-0. https://pubmed.ncbi.nlm.nih.gov/33830302/By studying data from very large-scale genome-wide association studies (GWAS) in European ancestry individuals, the authors compared genetic signals that confer risk of type 1 (T1DM) and type 2 diabetes (T2DM). Only 5 signals ...

Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island, USAcatherine.buck@yale.edu Obesity (Silver Spring). 2021 Jun;29(6):1036–1045. doi: 10.1002/oby.23160. https://pubmed.ncbi.nlm.nih.gov/34029449/Brief Summary: This longitudinal study assessed the ass...

To read the full abstract: Environmental health perspectives vol. 127,10 (2019): 107011. doi: https://ehp.niehs.nih.gov/doi/full/10.1289/EHP5570?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedThis study identifies the effects of exposure to environmentally rel...

J Perinat Med. 2019 Apr 24;47(3):347-353. doi: 10.1515/jpm-2018-0201.This study measured 8-hydroxy-deoxyguanosine (8-OH-dG), a marker of DNA oxidative damage, in venous umbilical cord plasma from newborns of mothers with and without a diabetes diagnosis during pregnancy.Adult offspring born to mothers with gestational diabetes mellitus (GDM) have an increased frequency...

To read the full abstract: Thyroid. 2019;29:595–606.Here, ultrastructural analysis of primary cilia in human thyroid follicles revealed a direct relationship between frequency and length of primary cilia and the functional state of the individual follicle in normal compared to hyperfunctioning thyroid tissues.Primary cilia are present in many different tissues...

To read the full abstract: Int J Obes 2019; 43(2): 384–91Studies regarding brown adipose tissue (BAT) activity in children are scarce due to the difficulties in detecting BAT by imaging and the need for elaborate techniques to measure BAT activity. Here, prepubertal children born small for gestational age (SGA, n=41) and children born appropriate for gestational age (AGA, <...

To read the full abstract: Development 2017;144:3289-3302Aberrant development of the anterior pituitary can lead to congenital hypopituitarism (CH) in humans and hence understanding how this organ develops is critical to understand CH. The anterior pituitary develops in intimate contact with the prospective hypothalamus, which secretes growth factors that are required for the pituitary gland to grow...

To read the full abstract: Mol Metab. 2017 Oct; 6(10): 1321–1329See comment on 11.7...

Nature. 2021 Jul;595(7867):455-459.Abstract: https://pubmed-ncbi-nlm-nih-gov/34194040/In brief: Using cryo-electron microscopy, the calcium-sensing receptor (CaSR) is visualized with different ligands demonstrating, in great detail, how calcimimetic drugs lock the CaSR homodimer in an assymetric configuration, exposing one of the two protomers for G-protein coupling, whereas calciolytic dru...

Lusc0001@umn.edu Obesity (Silver Spring) 2022, 30(5):1105–1115. https://doi.org/10.1002/oby.23395Brief Summary: This 52-week randomised placebo-controlled trial showed that exenatide XR improves stabilisation of BMI reduction after lifestyle intervention in adolescents with obesity.Maintaining weight loss after an in...