ISSN 1662-4009 (online)

ey0016.5-2 | New Therapies and Novel Therapeutic Strategies | ESPEYB16

5.2. Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment

F Zaman , Y Zhao , B Celvin , HH Mehta , J Wan , D Chrysis , C Ohlsson , B Fadeel , P Cohen , L Savendahl

Abstract: FASEB J. 2019;33:4962–4974.In brief: Glucocorticoid-induced growth impairment is reverted by the mitochondrial peptide humanin in dexamethasone-treated mice without attenuation of anti-inflammatory effects.Comment: Humanin (HN) is a 24 aminoacid peptide that was originally discovered as a neuroprotective factor and later shown ...

ey0015.7-8 | Genetic architecture of hypogonadotropic hypogonadism and delayed puberty | ESPEYB15

7.8 Congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty have distinct genetic architectures

D Cassatella , SR Howard , JS Acierno , C Xu , GE Papadakis , FA Santoni , AA Dwyer , S Santini , GP Sykiotis , C Chambion , J Meylan , L Marino , L Favre , J Li , X Liu , J Zhang , PM Bouloux , C Geyter , A Paepe , WS Dhillo , JM Ferrara , M Hauschild , M Lang-Muritano , JR Lemke , C Flück , A Nemeth , F Phan-Hug , D Pignatelli , V Popovic , S Pekic , R Quinton , G Szinnai , D l'Allemand , D Konrad , S Sharif , ÖT Iyidir , BJ Stevenson , H Yang , L Dunkel , N Pitteloud

To read the full abstract: Eur J Endocrinol. 2018 Apr;178(4):377-388[Comments on 7.7 and 7.8] Familial self-limited delayed puberty is highly heritable and has a clear genetic basis as described in the review written by Sasha Howard. Recent studies suggest that the genetic basis of self-limited delayed puberty is likely to be highly heteroge...

ey0015.1-1 | New mechanisms | ESPEYB15

1.1 Female sexual behavior in mice is controlled by kisspeptin neurons

V Hellier , O Brock , M Candlish , E Desroziers , M Aoki , C Mayer , R Piet , A Herbison , WH Colledge , V Prevot , U Boehm , J Bakker

To read the full abstract: Nat Commun 2018;9.400Pheromones play a crucial role to identify potential mates and sexual motivation in mice. These molecules are detected by a specialized circuit which initiates in the nasal septum and then relies on GnRH neurons in the hypothalamus in a sex-dependent manner. Female pheromones induce LH/testosterone release in male mice whereas male pheromones i...

ey0018.13-16 | Endocrinology | ESPEYB18

13.16. Maternal stature, maternal education and child growth in Pakistan: a cross-sectional study

N Javid , C Pu

AIMS Public Health 2020; 7(2): 380–392. doi: 10.3934/publichealth.2020032– Pakistan has a significantly higher prevalence of stunted children under 5 years old compared with other countries of the same income level. Stunting is more frequent in children of shorter compared to taller mothers– The authors hypothesized that higher maternal education, a modifiable factor, i...

ey0017.10-1 | (1) | ESPEYB17

10.1. Congenital infections as contributors to the onset of diabetes in children: A longitudinal study in the United States, 2001-2017

MAM Rogers , C Kim

To read the full abstract: Pediatr Diabetes. 2020;21(3):456–459.For many years, infections have been thought to trigger the onset of type 1 diabetes (T1DM) or even to be one of the causes of autoimmune processes that eventually lead to the destruction of the pancreatic beta-cell. In particular, maternal rubella virus infections during pregnancy are reported to increase the risk of T1DM in children, and fetal rubella infection leads to highe...

ey0019.4-3 | Important for clinical practice | ESPEYB19

4.3. Growth hormone treatment in the pre-transplant period is associated with superior outcome after pediatric kidney transplantation

C Jagodzinski , S Mueller , R Kluck , K Froede , L Pavicic , J Gellermann , D Mueller , U Querfeld , D Haffner , M Zivicnjak

Pediatr Nephrol, 2022. 37(4): p. 859-869 PMID: 34542703Brief Summary: This prospective observational cohort study investigated growth rate after kidney transplant in children with chronic kidney disease (CKD) and growth failure, who received or did not receive rhGH treatment before transplantation. Patients pre-treated with rhGH showed better growth rates with taller height SDS at 7 years after transplantation. Positive effects of pre-transplant...

ey0017.4-10 | New perspectives | ESPEYB17

4.10. IGF-I in cord blood is predictive of final height in monozygotic twins with intratwin birth weight differences

C Kasner , S Schulte , F Schreiner , R Fimmers , B Stoffel-Wagner , P Bartmann , J Woelfle , B Gohlke

To read the full abstract: Clin Endocrinol (Oxf) 2020 May 13. doi: 10.1111/cen.14221. Online ahead of print.Children born either small for gestational age (SGA) or preterm usually do not achieve a final height (FH) in the mid-parental target height (MPTH) range, despite showing catch-up growth in the first years of life (1). The influence of intrauterine metabolic and hormonal factors has been p...

ey0016.7-1 | Basic Science | ESPEYB16

7.1. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

RA Ross , S Leon , JC Madara , D Schafer , C Fergani , CA Maguire , AM Verstegen , E Brengle , D Kong , AE Herbison , UB Kaiser , BB Lowell , VM Navarro

To read the full abstract: Elife. 2018 Jun 15;7. pii: e35960.Using transgenic mice, this team discover a new role for Pituitary adenylate cyclase activating polypeptide (PACAP) in female puberty and reproduction. This neuropeptide relays nutritional state information in the hypothalamus to regulate gonadotropin-releasing hormone release.Metabolic cues play...

ey0019.3-2 | Thyroid hormone action | ESPEYB19

3.2. Congenital hypothyroidism and hyperthyroidism alters adrenal gene expression, development, and function

K Patyra , C Lof , H Jaeschke , H Undeutsch , HS Zheng , S Tyystjarvi , K Puławska , M Doroszko , M Chruściel , BM Loo , R Kurkijarvi , FP Zhang , CJ Huang , C Ohlsson , A Kero , M Poutanen , J Toppari , R Paschke , N Rahman , I Huhtaniemi , J Jaaskelainen , J Kero

Thyroid. 2022 Apr;32(4):459-471. doi: 10.1089/thy.2021.0535. PMID: 35044245Brief Summary: This study combines animal model and patient cohort data on the effect of hyperthyroidism and hypothyroidism at birth on adrenal gland development and function. The data revealed reciprocal effects of neonatal hyper- and hypothyroidism on adrenal development, activity of the adrenal steroidogenic pathway a...

ey0018.10-1 | (1) | ESPEYB18

10.1. Did the COVID-19 lockdown affect the incidence of pediatric type 1 diabetes in Germany?

SR Tittel , J Rosenbauer , C Kamrath , J Ziegler , F Reschke , J Hammersen , K Monkemoller , A Pappa , T Kapellen , RW Holl , Initiative DPV

Diabetes Care. 2020;43(11):e172–e173. doi: 10.2337/dc20-1633During the first phase of the COVID-19 pandemic, the DPV (the German diabetes registry database) study group asked whether or not the COVID-19 lockdown had affected the incidence of pediatric T1D in Germany (1). More than 210 German pediatric diabetes centers contributed their data on pediatric patients with T1D with an onset at ag...